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課程資訊 |
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課程名稱 |
結構生物學與生物資訊特論 Structural Biology & Bioninformatics | ||||||||||||||||
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開課學期 |
107-1 | ||||||||||||||||
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授課對象 |
生物資源暨農學院 生物科技研究所 | ||||||||||||||||
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授課教師 |
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課號 |
Biot8003 | ||||||||||||||||
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課程識別碼 |
642 D0040 | ||||||||||||||||
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班次 |
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學分 |
3.0 | ||||||||||||||||
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全/半年 |
半年 | ||||||||||||||||
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必/選修 |
必修 | ||||||||||||||||
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上課時間 |
星期五6,7,8(13:20~16:20) | ||||||||||||||||
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上課地點 |
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備註 |
限博士班 總人數上限：20人 外系人數限制：15人 | ||||||||||||||||
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1071Biot8003_ | ||||||||||||||||
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 | ||||||||||||||||
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課程大綱
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課程概述 |
This is a class integrates the concepts of structural biology and bioinformatics. The basic principles of amino acids and structural biology will be explained first, then the modern methods to resolve atomic resolution of protein structures. The relation of protein structure and function will be emphasized in the third part of this class. Bioinformatics principles, methods and modern developments will be followed. | ||||||||||||||||
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課程目標 |
1. Understand amino acids and protein structures.
2. Modern approaches to resolve protein structure. 3. Protein structure and function. 4. Software-based analysis of protein sequence. 5. Bioinformatic theories 6. Current developments of bioinformatics methods. | ||||||||||||||||
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課程要求 |
This class will be taught in English. | ||||||||||||||||
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
Most recent published journal articles. | ||||||||||||||||
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參考書目 |
1. David Whitford (2005). Proteins : Structure and Function. John Wiley & Sons, Hoboken, NJ. USA.
2. Gregory A. Petsko and Dagmar Ringe (2003). Protein Structure and Function, 4th ed., New Science Press, Waltham, MA. 3. Materials are updated when new developments occur. | ||||||||||||||||
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評量方式 (僅供參考) |
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課程進度 |
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週次 |
日期 |
單元主題 |
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第1週 |
9/14 | 1) What will be taught in this class
2) Introduction of Structural Biology |
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第2週 |
9/21 | Software tools for structural biology
Amino acids and protein structures (1/2) |
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第3週 |
9/28 | 1) Amino Acids and protein structures (2/2)
2) Five Secondary protein structure |
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第4週 |
10/05 | Five Domain arrangements in protein structure
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第5週 |
10/12 | 1) Protien Domains
2) Modern methods for structural biology (1): PDB display software |
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第6週 |
10/19 | Modern methods for structural biology (2): X-ray diffraction & CryoEM |
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第7週 |
10/26 | BYOC: Bring your own computer; Let's do animation!
Life science and structural biology (1): Cellular functions, Membrane proteins |
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第8週 |
11/02 | Bioinformatics and Software Tools Demonstration |
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第9週 |
11/09 | Oral presentations
Midterm Exam (Final for Structural Biology Part) |
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第10週 |
Introduction of bioinformatics | |
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第11週 |
Transcriptome: Microarray introduction (1) | |
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第12週 |
Microarry (2): Data analysis | |
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第13週 |
NTUMAPs and IPA demostration | |
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第14週 |
NGS introduction | |
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第15週 |
NGS partek flow demonstration | |
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第16週 |
Genetic and population analysis: SNP introduction | |
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第17週 |
DNA copy number variation | |
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第18週 |
Final Exam |